细胞外小泡
纳米技术
计算机科学
微流控
数据科学
工程伦理学
管理科学
风险分析(工程)
工程类
医学
材料科学
生物
细胞生物学
作者
Zesheng Wang,Xiaoyu Zhou,Qinglong Kong,Huimin He,Jiayu Sun,Wenting Qiu,Liang Zhang,Mengsu Yang
标识
DOI:10.1002/advs.202401069
摘要
Abstract In recent decades, research on Extracellular Vesicles (EVs) has gained prominence in the life sciences due to their critical roles in both health and disease states, offering promising applications in disease diagnosis, drug delivery, and therapy. However, their inherent heterogeneity and complex origins pose significant challenges to their preparation, analysis, and subsequent clinical application. This review is structured to provide an overview of the biogenesis, composition, and various sources of EVs, thereby laying the groundwork for a detailed discussion of contemporary techniques for their preparation and analysis. Particular focus is given to state‐of‐the‐art technologies that employ both microfluidic and non‐microfluidic platforms for EV processing. Furthermore, this discourse extends into innovative approaches that incorporate artificial intelligence and cutting‐edge electrochemical sensors, with a particular emphasis on single EV analysis. This review proposes current challenges and outlines prospective avenues for future research. The objective is to motivate researchers to innovate and expand methods for the preparation and analysis of EVs, fully unlocking their biomedical potential.
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