Association of Sugar-Sweetened, Artificially Sweetened, and Unsweetened Coffee Consumption With All-Cause and Cause-Specific Mortality

LettersJanuary 2023Association of Sugar-Sweetened, Artificially Sweetened, and Unsweetened Coffee Consumption With All-Cause and Cause-Specific MortalityDan Liu, MD, Qingmei Huang, MD, Weiqi Song, MD, Zhihao Li, MD, Chen Mao, MDDan Liu, MDDepartment of Epidemiology, School of Public Health, Southern Medical University, and Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, ChinaSearch for more papers by this author, Qingmei Huang, MDDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, ChinaSearch for more papers by this author, Weiqi Song, MDDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, ChinaSearch for more papers by this author, Zhihao Li, MDDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, ChinaSearch for more papers by this author, Chen Mao, MDDepartment of Epidemiology, School of Public Health, and Department of Laboratory Medicine, Microbiome Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L22-0369 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE: As suggested by Drs. Harada and Harada Sassa, we performed stratified analyses by ethnicity (Supplement Figure of our article). We found that moderate coffee consumption with and without sugar was associated with lower all-cause and cancer mortality in White participants. Insignificant associations in other ethnic groups may be due to small sample size. Given the observational nature of the study, residual confounding may also be present even if confounding factors were thoroughly adjusted in Cox regression models. We acknowledge this issue in the Discussion section of our article.Mendelian randomization studies may be less affected by confounding, but ...References1. Wee CC. The potential health benefit of coffee: does a spoonful of sugar make it all go away? [Editorial]. Ann Intern Med. 2022;175:1035-6. [PMID: 35635845] doi:10.7326/M22-1465 LinkGoogle Scholar2. Ong JS, Law MH, An J, et al. Association between coffee consumption and overall risk of being diagnosed with or dying from cancer among > 300 000 UK Biobank participants in a large-scale Mendelian randomization study. Int J Epidemiol. 2019;48:1447-56. [PMID: 31412118] doi:10.1093/ije/dyz144 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Dan Liu, MD; Qingmei Huang, MD; Weiqi Song, MD; Zhihao Li, MD; Chen Mao, MDAffiliations: Department of Epidemiology, School of Public Health, Southern Medical University, and Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, ChinaDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, ChinaDepartment of Epidemiology, School of Public Health, and Department of Laboratory Medicine, Microbiome Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaDisclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M21-2977. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAssociation of Sugar-Sweetened, Artificially Sweetened, and Unsweetened Coffee Consumption With All-Cause and Cause-Specific Mortality Dan Liu , Zhi-Hao Li , Dong Shen , Pei-Dong Zhang , Wei-Qi Song , Wen-Ting Zhang , Qing-Mei Huang , Pei-Liang Chen , Xi-Ru Zhang , and Chen Mao Association of Sugar-Sweetened, Artificially Sweetened, and Unsweetened Coffee Consumption With All-Cause and Cause-Specific Mortality Kouji H. Harada and Mariko Harada Sassa Metrics Cited byAssociation of milk consumption with all-cause mortality and cardiovascular outcomes: a UK Biobank based large population cohort study January 2023Volume 176, Issue 1KeywordsBiobanksCardiovascular diseasesCoffeeDietExerciseHypertensionMortalityPrevention, policy, and public healthQuestionnaires ePublished: 17 January 2023 Issue Published: January 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...