Magnetic capture of sulfur quantum dots encapsulated in MOF-5-NH2 via a target-driven self-cycling catalyzed hairpin assembly for the sensitive detection of patulin

荧光 展青霉素 量子点 色谱法 化学 适体 组合化学 纳米技术 检出限 材料科学 自来水 真菌毒素 分子生物学 环境工程 生物 物理 工程类 量子力学 食品科学
作者
Xiaohai Yan,Yuning Zhao,Gengan Du,Qi Guo,Hong Chen,Qian He,Qiannan Zhao,Huanfeng Ye,Jianlong Wang,Yahong Yuan,Tianli Yue
出处
期刊:Chemical Engineering Journal [Elsevier BV]
卷期号:433: 133624-133624 被引量:49
标识
DOI:10.1016/j.cej.2021.133624
摘要

Tools to detect low molecular weight mycotoxin patulin (PAT) are urgently needed because of its harm to human health. Here, we report a simple, effective, and sensitive fluorescent aptasensor based on sulfur quantum dots encapsulated in MOF-5-NH2 ([email protected]2) and self-cycling catalyzed hairpin assembly (scCHA) for the detection of PAT in apple juice. The [email protected]2 synthesized by a “bottle-around-ship” solvothermal method works as a fluorescent probe and offers enhanced fluorescence intensity and good water-solubility versus MOF-5-NH2 due to the encapsulation of water-soluble SQDs. Meanwhile, the scCHA designed by the two DNA hairpins is initiated after the formation of PAT/aptamer, which further recycles PAT to effectively capture multiple fluorescence probes ([email protected]2) and amplify the detection signal. Attributed to the synergistic effect between the strong fluorescence intensity of [email protected]2 and the efficient PAT utilization of scCHA, the fluorescent aptasensor exhibits high sensitivity with detection limits as low as 0.753 pg/mL. The system has satisfactory specificity, anti-interference, and reproducibility (RSDs of intra-assay and inter-assay were 3.24% and 8.60%, respectively). The recoveries in apple juice were between 89.03% and 107.67%, which were with good consistency versus high-performance liquid chromatography (HPLC). These data collectively show that the developed fluorescent aptasensor has a good practical application value.
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