恩帕吉菲
赖诺普利
医学
疾病
糖尿病
药理学
肾
2型糖尿病
生物信息学
内科学
内分泌学
血压
血管紧张素转换酶
生物
作者
Morten Østergaard,Thomas Secher,Michael Christensen,Casper Gravesen Salinas,Urmas Roostalu,Jacob Lercke Skytte,Ida Rune,Henrik H. Hansen,Jacob Jelsing,Niels Vrang,Lisbeth N. Fink
出处
期刊:American Journal of Physiology-renal Physiology
[American Physiological Society]
日期:2021-08-01
卷期号:321 (2): F149-F161
被引量:18
标识
DOI:10.1152/ajprenal.00154.2021
摘要
Translational animal models of diabetic kidney disease (DKD) are important tools in preclinical research and drug discovery. Here, we show that standard of care to control hypertension (lisinopril) and hyperglycemia (empagliflozin) improves kidney physiological and histopathological hallmarks in a mouse model of hypertension-accelerated progressive DKD. The findings substantiate hypertension and type 2 diabetes as essential factors in driving DKD progression, and provide proof-of-concept for probing novel drugs for potential nephroprotective efficacy in this model.
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