刚度
体内分布
药物输送
纳米技术
渗透(战争)
材料科学
纳米颗粒
纳米医学
靶向给药
生物物理学
化学
复合材料
工程类
生物化学
体外
生物
运筹学
作者
Stephanie Kong,Daniel F. Costa,Anna Jagielska,Krystyn J. Van Vliet,Paula T. Hammond
标识
DOI:10.1073/pnas.2104826118
摘要
Significance Layer-by-layer nanoparticles (LbL NPs), comprised of a charged core substrate layered sequentially with oppositely charged polyelectrolytes, are a promising class of drug delivery carriers for cancer therapeutics with demonstrated success in lowering off-target toxicity and enhancing efficacy. However, little is known about how LbL NP stiffness alters trafficking and delivery. Herein, we report that the stiffness of targeted LbL NPs, comprised of a liposome core and tumor-targeting, polymeric outer layers, can be tuned by altering the mechanical properties of its underlying liposomal core. We also show that these changes have a significant impact on in vivo NP trafficking properties; compliant LbL NPs have longer elimination times, higher organ and tumor accumulation, and higher tumor penetration.
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