普鲁兰
生物粘附
杜克雷嗜血杆菌
剪切减薄
色谱法
化学
终结者
触变性
流变学
生物医学工程
聚合物
材料科学
复合材料
多糖
传统医学
有机化学
生物化学
医学
抗生素
流感嗜血杆菌
巴氏杆菌科
作者
Radhika Sharma,Vikas Rana
标识
DOI:10.1016/j.ijbiomac.2021.10.179
摘要
In present work, a film forming gel (FFG) was developed through ingenious amalgamation of polymers: Pullulan, Terminalia catappa and Carbopol®971P ® for cutaneous delivery of clotrimazole (CTZ) employing D-optimal mixture design. The developed FFG possess pseudoplastic, viscoelastic, thixotropic characteristics leading to good spreadability (35.71 ± 1.72 g·s, work of shear; 452.73 ± 8.23 g, firmness). Upon solvent evaporation, FFG converted in situ into bioadhesive film (81.90 ± 3.24 g) leading to longer residence on skin surface, prolonged delivery and ~1.3 fold enhanced CTZ skin retention as compare to commercial cream as evident from biopharmaceutical analysis, which is ideal for skin infections treatment. The simulation analysis suggested ≥10 μg/mL (MIC against C. albicans) CTZ concentration maintained for 2 times the days in rat skin as well as human skin as compared to commercial cream. Overall, the developed FFG system ascertained to be promising delivery system for treatment of chronic skin conditions.
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