Supramolecular self-assembly and perfectedin vitro/vivoproperty of 5-fluorouracil and ferulic acid on the strength of double optimized strategy: the first 5-fluorouracial-phenolic acid nutraceutical cocrystal with synergistic antitumor efficacy

The first 5-fluorouracil-nutraceutical cocrystal with synergistic antitumor effect, Flu-FR-H₂O, is synthesized based on the dual optimization strategy and evaluated by combining the experimental evaluation with theoretical analysis.