高果糖玉米糖浆
心理学
玉米糖浆
多巴胺
多巴胺受体D2
内分泌学
内科学
果糖
发展心理学
神经科学
化学
食品科学
医学
作者
Alex Maya-Romero,Gina E. Dodd,Justine D. Landin,H Zaremba,Omar F. Allen,Mackenzie A. Bilbow,Rhyce D. Hammaker,Jessica L. Santerre-Anderson
标识
DOI:10.1016/j.bbr.2021.113687
摘要
Adolescence is a critical period of development, during which the brain undergoes rapid maturation. Problematically, adolescents are the top consumers of high fructose corn syrup (HFCS) sweetened beverages and snacks, which may have neurodevelopmental consequences. While HFCS consumption has been linked to an increased likelihood of obesity and other physical health impairments, the link between HFCS and persistent behavioral changes is not yet fully established. The present study aimed to assess whether adolescent HFCS consumption could lead to alterations in adult behaviors and protein expression, following cessation. Adolescent HFCS-exposure contributed to deficits in learning and motivation on an effort-related T-Maze procedure, as well as increased immobility time in the forced swim paradigm during adulthood. Molecularly, protracted decreases in accumbal dopamine D1 and D2 receptors and protein kinase G (PKG), as well as increases in tyrosine hydroxylase and GluA2 receptor subunits, were observed following HFCS-exposure. Taken together, these data suggest that adolescent HFCS-consumption leads to protracted dysfunction in affective behaviors and alterations in accumbal proteins which persist following cessation of HFCS-consumption.
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