Overcoming the Naphthyl Requirement in Stereospecific Cross-Couplings to Form Quaternary Stereocenters

The use of a simple stilbene ligand has enabled a stereospecific Suzuki–Miyaura cross-coupling of tertiary benzylic carboxylates, including those lacking naphthyl substituents. This method installs challenging all-carbon diaryl quaternary stereocenters in good yield and ee and represents an important breakthrough in the “naphthyl requirement” that pervades stereospecific cross-couplings involving enantioenriched electrophiles.