化学
炔丙基
双金属片
烯类反应
催化作用
分子内力
路易斯酸催化
路易斯酸
药物化学
盐(化学)
有机化学
作者
Pathan Mosim Amin,Qi Cui,Shaozhong Wang,Zhi‐Xiang Yu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-07-13
卷期号:23 (15): 5669-5673
被引量:8
标识
DOI:10.1021/acs.orglett.1c01782
摘要
A bimetallic protocol has been developed to construct (Z)-γ-alkylidenebutenolide compounds from readily available propargyl α-ketoesters. It involves a gold-catalyzed 1,3-acyloxy migration of propargyl α-ketoesters and a carbonyl-ene cyclization of in situ generated allenyl esters. DFT calculations suggest that the copper salt might play dual roles as both chloride abstractor facilitating the generation of highly active gold catalyst and Lewis acid promoting the stepwise intramolecular carbonyl-ene reaction.
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