MPTP公司
纹状体
帕金森病
多巴胺转运体
灵长类动物
多巴胺
医学
发病机制
单光子发射计算机断层摄影术
神经科学
疾病
麻醉
心理学
内科学
多巴胺能
作者
Jun Li,Huiyun Zhang,Yong Jiang,Tianqing Li
出处
期刊:PubMed
日期:2017-12-25
卷期号:69 (6): 743-750
被引量:1
摘要
Parkinson's disease (PD) is one of the most common neurodegenerative diseases, but its pathogenesis is still unclear. Recently a new approach has been used to develop Parkinsonian monkeys with unilateral intracerebroventricular injections of 1-methyl-4-phenylpyridinium ion (MPP+). However, this new method still has some shortcomings, which limits the potential application of MPTP-induced PD monkey models. In the present study, we aimed to develop a modified protocol to induce chronic Parkinsonian non-human primate model with low-dose MPP+ by bilateral intracerebroventricular injections. The induced time of PD model, model stability, phenotypes and 99Tcm-TRODAT-1 single-photon emission computed tomography (SPECT) brain imaging of dopamine transporter were compared between unilateral and bilateral modeling groups. The results showed that PD symptoms in the bilateral modeling group were induced earlier, more serious, and lasted longer after the administration stage, compared with those of the unilateral modeling group. In the unilateral modeling group, radioactive uptake of the striatum was decreased significantly in the left side (MPP+ injected side), but unaffected in the right side. While in the bilateral modeling group, the radioactive uptake of the bilateral striatum was declined dramatically and symmetrically. These results suggest that bilateral intracerebroventricular injection of MPP+ is superior to unilateral intracerebroventricular injection in establishing chronic Parkinsonian non-human primate model and may supply a better animal model for PD research.
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