对映选择合成
亚胺离子
氧化剂
炔基化
催化作用
电化学
化学
四氢异喹啉
氧化还原
铜
药物化学
组合化学
配体(生物化学)
甲烷氧化偶联
有机化学
电极
受体
物理化学
生物化学
作者
Pei‐Sen Gao,Xin‐Jun Weng,Zhen‐Hua Wang,Chao Zheng,Bing Sun,Zhihao Chen,Shu‐Li You,Tian‐Sheng Mei
标识
DOI:10.1002/anie.202005099
摘要
Abstract A novel strategy for asymmetric Shono‐type oxidative cross‐coupling has been developed by merging copper catalysis and electrochemistry, affording C1‐alkynylated tetrahydroisoquinolines with good to excellent enantioselectivity. The use of TEMPO as a co‐catalytic redox mediator is crucial not only for oxidizing a tetrahydroisoquinoline to an iminium ion species but also for decreasing the oxidation potential of the reaction. A novel bisoxazoline ligand is also reported.
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