肝细胞癌
免疫组织化学
癌症研究
阶段(地层学)
临床意义
肿瘤进展
癌症
医学
病理
生物
肿瘤科
内科学
古生物学
作者
Yulong He,Zhaohui Zheng,Yi Xu,Hui-Wen Weng,Ying Gao,Kai Qin,Jian Rong,Chen Cui,Yun Miao,Jiaxing Zhang,Sheng Ye
出处
期刊:PubMed
日期:2018-01-01
卷期号:8 (8): 1604-1614
被引量:10
摘要
Inosine monophosphate dehydrogenase type II (IMPDH2) has been found to play critical roles in the development and progression of several human cancers. However, the expression of IMPDH2 and its clinical significance in hepatocellular carcinoma (HCC) is little known. The expression of IMPDH2 in HCC cell lines and tissues were evaluated by Western blotting (WB), quantitative real-time PCR (q-PCR) and immunohistochemistry (IHC). We found that the expression of IMPDH2 was significantly up-regulated in HCC tissues than in adjacent non-tumorous tissues, and this was correlated with several clinicopathological features, including tumor multiplicity (P=0.001), TNM stage (P<0.001). Moreover, the Cox regression analysis suggested that the expression of IMPDH2 was an independent prognostic factor for overall survival (P<0.0001) and progression-free survival (P<0.0001). Further study showed that up-regulation of IMPDH2 expression increased the proliferation and tumorigenicity of HCC cells in vitro, by promoting cell growth rate, colony formation. Together, our results demonstrated that the over-expression of IMPDH2 was closely associated with poor survival outcome in patients with HCC and may present a novel prognostic and therapeutic target for this disease.
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