Diagnostic challenge of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome in pediatric age: A monocentric case series

萨福综合征 医学 脓疱病 骨质增生 骨炎 掌跖脓疱病 滑膜炎 皮肤病科 痤疮 炎症性肠病 痹症科 内科学 儿科 疾病 关节炎 外科 银屑病 骨髓炎
作者
Ilaria Maccora,Edoardo Marrani,Valerio Maniscalco,Maria Vincenza Mastrolia,Ilaria Pagnini,Gabriele Simonini
出处
期刊:Modern Rheumatology [Informa]
卷期号:31 (6): 1228-1231 被引量:5
标识
DOI:10.1080/14397595.2021.1892264
摘要

SAPHO syndrome is a rare disease that typically begins in the third-fifth decade of life, and is characterized by osteoarticular and dermatologic features [1]. The acronym summarizes the key clinical features: synovitis, acne, palmoplantar pustulosis, hyperostosis and osteitis [2]. The prevalence of this condition is estimated to be less than 1 per 10,000 people [3]. Several cases have been described in childhood, mostly in adolescents, some associated with other comorbidities. Indeed, the SAPHO clinical spectrum encompasses a wide range of different manifestations which overlap with other autoimmune or autoinflammatory disorders, thus often challenging the diagnosis, particularly in paediatric age [4–6]. If promptly recognized and adequately treated, SAPHO syndrome shows a favourable course. Herein we present a case series of 5 children affected by SAPHO syndrome, diagnosed at our Rheumatology Unit from March 2015 to June 2020, experiencing an excellent response to anti-TNFα. Five Caucasian patients (3 males) with a median age of 12 years and 5 months (range 132-192 months) received a diagnosis of SAPHO syndrome (Table 1). The median time between disease onset and diagnosis was 6 months (range 3–22 months). Patient #1 and #2 had a previous diagnosis of Inflammatory Bowel Diseases (IBD) – Crohn disease (CD) and Ulcerative colitis (UC), respectively; no other previous or concomitant relevant medical conditions were reported for the other patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
幽壑之潜蛟应助Ruoru采纳,获得10
1秒前
良辰应助简单的储采纳,获得10
1秒前
俊逸翠丝完成签到,获得积分10
2秒前
优雅的棉花糖完成签到,获得积分10
3秒前
儒雅的夏山完成签到,获得积分10
4秒前
Alara发布了新的文献求助10
5秒前
7秒前
在水一方应助hopen采纳,获得10
8秒前
8秒前
鸢雨情笺发布了新的文献求助10
8秒前
结实的元灵完成签到,获得积分10
9秒前
T1unkillable完成签到 ,获得积分10
10秒前
积极若风完成签到,获得积分10
11秒前
WQ发布了新的文献求助10
11秒前
就在日落以后完成签到 ,获得积分10
11秒前
顾矜应助yinss采纳,获得10
12秒前
清秀的大山完成签到,获得积分10
13秒前
jw发布了新的文献求助10
13秒前
14秒前
柚柚关注了科研通微信公众号
16秒前
枳甜完成签到,获得积分20
19秒前
19秒前
20秒前
科研通AI5应助BINGOFAN采纳,获得10
21秒前
Xxanny应助笨笨的从寒采纳,获得20
22秒前
细胞疗法搬砖工完成签到,获得积分10
23秒前
24秒前
bear完成签到,获得积分10
24秒前
fugu0完成签到,获得积分10
24秒前
科研通AI5应助lilian采纳,获得10
25秒前
CipherSage应助科研通管家采纳,获得10
26秒前
小蘑菇应助科研通管家采纳,获得10
26秒前
烟花应助科研通管家采纳,获得10
26秒前
JamesPei应助科研通管家采纳,获得10
26秒前
pluto应助科研通管家采纳,获得10
26秒前
苏卿应助科研通管家采纳,获得10
26秒前
在水一方应助科研通管家采纳,获得10
27秒前
小二郎应助科研通管家采纳,获得10
27秒前
科研通AI5应助科研通管家采纳,获得10
27秒前
27秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Conference Record, IAS Annual Meeting 1977 820
England and the Discovery of America, 1481-1620 600
電気学会論文誌D(産業応用部門誌), 141 巻, 11 号 510
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3572963
求助须知:如何正确求助?哪些是违规求助? 3143128
关于积分的说明 9450156
捐赠科研通 2844589
什么是DOI,文献DOI怎么找? 1563562
邀请新用户注册赠送积分活动 731886
科研通“疑难数据库(出版商)”最低求助积分说明 718701