伏隔核
扣带回前部
光遗传学
神经科学
心理学
扁桃形结构
基底外侧杏仁核
移情
被盖腹侧区
扣带皮质
精神科
中枢神经系统
多巴胺
认知
多巴胺能
作者
Monique L. Smith,Naoyuki Asada,Robert C. Malenka
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2021-01-07
卷期号:371 (6525): 153-159
被引量:236
标识
DOI:10.1126/science.abe3040
摘要
Empathy is an essential component of social communication that involves experiencing others’ sensory and emotional states. We observed that a brief social interaction with a mouse experiencing pain or morphine analgesia resulted in the transfer of these experiences to its social partner. Optogenetic manipulations demonstrated that the anterior cingulate cortex (ACC) and its projections to the nucleus accumbens (NAc) were selectively involved in the social transfer of both pain and analgesia. By contrast, the ACC→NAc circuit was not necessary for the social transfer of fear, which instead depended on ACC projections to the basolateral amygdala. These findings reveal that the ACC, a brain area strongly implicated in human empathic responses, mediates distinct forms of empathy in mice by influencing different downstream targets.
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