Recent Advances in Targeted Therapy for Glioma

Gliomas are the most common primary malignant brain tumors, which have a universally fatal outcome. Current standard treatment for glioma patients is surgical removal followed by radiotherapy and adjuvant chemotherapy. Due to therapeutic resistance and tumor recurrence, efforts are ongoing to identify the molecules that are fundamental to regulate the tumor progression and provide additional methods for individual treatment of glioma patients. Keywords: Glioma, clinical trials, targeted therapy, cell signal transduction pathway, glioma stem cell, Immunotherapy.