Hydrophobic Drug-Loaded PEGylated Magnetic Liposomes for Drug-Controlled Release

脂质体 姜黄素 药物输送 药品 材料科学 靶向给药 毒品携带者 细胞毒性 纳米技术 磁性纳米粒子 聚乙二醇化 药理学 化学 体外 生物物理学 纳米颗粒 聚乙二醇 医学 生物化学 生物
作者
Andri Hardiansyah,Ming-Chien Yang,Tingyu Liu,Chung-Wen Kuo,Li-Ying Huang,Tzu-Yi Chan
出处
期刊:Nanoscale Research Letters [Springer Nature]
卷期号:12 (1) 被引量:53
标识
DOI:10.1186/s11671-017-2119-4
摘要

Less targeted and limited solubility of hydrophobic-based drug are one of the serious obstacles in drug delivery system. Thus, new strategies to enhance the solubility of hydrophobic drug and controlled release behaviors would be developed. Herein, curcumin, a model of hydrophobic drug, has been loaded into PEGylated magnetic liposomes as a drug carrier platform for drug controlled release system. Inductive magnetic heating (hyperthermia)-stimulated drug release, in vitro cellular cytotoxicity assay of curcumin-loaded PEGylated magnetic liposomes and cellular internalization-induced by magnetic guidance would be investigated. The resultant of drug carriers could disperse homogeneously in aqueous solution, showing a superparamagnetic characteristic and could inductive magnetic heating with external high-frequency magnetic field (HFMF). In vitro curcumin release studies confirmed that the drug carriers exhibited no significant release at 37 °C, whereas exhibited rapid releasing at 45 °C. However, it would display enormous (three times higher) curcumin releasing under the HFMF exposure, compared with that without HFMF exposure at 45 °C. In vitro cytotoxicity test shows that curcumin-loaded PEGylated magnetic liposomes could efficiently kill MCF-7 cells in parallel with increasing curcumin concentration. Fluorescence microscopy observed that these drug carriers could internalize efficiently into the cellular compartment of MCF-7 cells. Thus, it would be anticipated that the novel hydrophobic drug-loaded PEGylated magnetic liposomes in combination with inductive magnetic heating are promising to apply in the combination of chemotherapy and thermotherapy for cancer therapy.

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