Toxicity, Teratogenicity and Anti-cancer Activity of α-solanine: A Perspective on Anti-cancer Potential

The "-Solanine is a glycoalkaloid metabolite produced by solanaceae species, important plant food in the human nutrition.This "-solanine is highly toxic to animals and humans and has been indicated as a risk factor for developing congenital malformations.However, recent studies suggest that "-solanine possesses anti-microbial and anti-tumor activities.The aim of this review was to summarize the main properties of "-solanine, its toxicity and teratogenicity in animal models and the main findings reported about anticancer activity against various cancer cell lines in in vitro assays.Key "-solanine mechanisms of action are presented alongside arising interdisciplinary research, connecting agricultural sciences and medicine.Data presented in this review, may assisted in preventing toxic effects of "-solanine and promote research about its potential use in the treatment and management of human cancers.