重编程
肿瘤微环境
癌症
免疫疗法
生物
免疫系统
瓦博格效应
癌症免疫疗法
厌氧糖酵解
癌症研究
免疫检查点
免疫
医学
癌细胞
免疫学
免疫监视
效应器
癌症治疗
炎症
细胞
生物化学
遗传学
作者
Chunqing Guo,Shixian Chen,Wenjie Liu,Yibao Ma,Juan Li,Paul B. Fisher,Xianjun Fang,Xiangyang Wang
出处
期刊:Advances in Cancer Research
日期:2019-01-01
卷期号:: 195-253
被引量:28
标识
DOI:10.1016/bs.acr.2019.03.004
摘要
Fundamental metabolic pathways are essential for mammalian cells to provide energy, precursors for biosynthesis of macromolecules, and reducing power for redox regulation. While dysregulated metabolism (e.g., aerobic glycolysis also known as the Warburg effect) has long been recognized as a hallmark of cancer, recent discoveries of metabolic reprogramming in immune cells during their activation and differentiation have led to an emerging concept of "immunometabolism." Considering the recent success of cancer immunotherapy in the treatment of several cancer types, increasing research efforts are being made to elucidate alterations in metabolic profiles of cancer and immune cells during their interplays in the setting of cancer progression and immunotherapy. In this review, we summarize recent advances in studies of metabolic reprogramming in cancer as well as differentiation and functionality of various immune cells. In particular, we will elaborate how distinct metabolic pathways in the tumor microenvironment cause functional impairment of immune cells and contribute to immune evasion by cancer. Lastly, we highlight the potential of metabolically reprogramming the tumor microenvironment to promote effective and long-lasting antitumor immunity for improved immunotherapeutic outcomes.
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