硒
人类健康
疾病
糖尿病
炎症
不利影响
癌症
重症监护医学
生物信息学
毒理
免疫学
生理学
内科学
医学
内分泌学
生物
环境卫生
化学
有机化学
作者
Regina Brigelius‐Flohé
出处
期刊:Molecular and integrative toxicology
日期:2018-01-01
卷期号:: 3-26
被引量:34
标识
DOI:10.1007/978-3-319-95390-8_1
摘要
Since its detection in 1817 selenium underwent an adventurous trip from a toxic to an essential element. As integral part of selenoproteins it was assumed that it is capable to prevent or even cure diseases. The trip was slowed with the findings that, when overdosed, selenium still can have toxic effects. Thus, an optimal intake and status had to be evaluated. It became clear that the plasma selenium level should neither substantially fall below nor exceed a value around 120 μg/L. Success and failure of human studies undertaken to find a beneficial effect of selenium supplementation in cancer, inflammation and immune response, cardiovascular diseases, thyroiditis, male fertility, and the surprising adverse effect, diabetes, are shortly summarized, and functions of involved selenoproteins and underlying mechanisms discussed. To provide recommendations, more studies with better comparability regarding form, dosage, and duration of a supplementation are needed and still unknown functions of selenoproteins identified.
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