Hybrid‐stenting with metallic and bioresorbable drug‐eluting stents 2‐year clinical outcomes in KUM ABSORB registry

医学 心肌梗塞 入射(几何) 累积发病率 裸金属 狭窄 内科学 靶病变 病变 心脏病学 血运重建 外科 支架 再狭窄 经皮冠状动脉介入治疗 队列 物理 光学
作者
Moritz Baquet,David Grundmann,Wolfgang Schmidt,Manuela Thienel,David Jochheim,Christian Tesche,Hans Theiß,Stefan Brunner,Steffen Maßberg,Julinda Mehilli
出处
期刊:Catheterization and Cardiovascular Interventions [Wiley]
卷期号:93 (1): 71-78 被引量:2
标识
DOI:10.1002/ccd.27832
摘要

Abstract Aim and Objective We sought to investigate and compare outcomes 2 years after Hybrid‐stenting with bioresorbable vascular scaffolds (BVS) and contemporary metallic drug‐eluting stents (DES) within the same coronary lesion versus BVS alone. Methods Between 11/2012 and 7/2015 at our institution, 134 (33.2%) were treated with Hybrid‐stenting for complex or long coronary lesions, 270 patients were treated by BVS alone. The primary outcome of interest was target lesion failure (TLF) at 2‐years of follow‐up. Results Patients treated by Hybrid‐stenting were more frequently men (80% vs. 70%, p = 0.04) had extensive multivessel disease (84% vs. 71%, p < 0.01) including more complex (89% vs. 52%, p < 0.01) and longer lesions (28.9 mm vs 16.4 ± mm, p < 0.01) resulting in longer treated segments (47.3 mm vs 21.5 mm, p < 0.01) and more residual in‐segment stenosis (12.3% vs 8.5%, p < 0.01) compared to BVS alone patients. At 2 years, cumulative incidence of TLF was 9.7% of Hybrid‐stenting patients and 11.5% of BVS alone patients (p = 0.62), myocardial infarction (3.0% vs 4.1%, p = 0.59) and mortality (1.5% vs 4.1%, p = 0.17), respectively. Target lesion revascularization occurred in 9 Hybrid‐stenting patients (2 located in DES) and in 20 BVS alone patients, cumulative incidence 6.7% vs. 7.4% (p = 0.80). Chronic kidney disease and residual in‐segment stenosis >30% were identified as independent predictors of TLF at 2‐years. Conclusion Despite differences in clinical and angiographic profile, Hybrid‐stenting performed similar to BVS alone at 2 years after percutaneous coronary intervention.
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