多样性(政治)
遗传多样性
生物
人类免疫缺陷病毒(HIV)
病毒学
选择(遗传算法)
艾滋病疫苗
进化生物学
遗传学
计算生物学
人口
医学
政治学
计算机科学
疫苗试验
环境卫生
人工智能
法学
作者
Brian Gaschen,Jesse E. Taylor,Karina Yusim,Brian Foley,Feng Gao,Dorothy Lang,Vladimir Novitsky,Barton F. Haynes,Beatrice H. Hahn,Tanmoy Bhattacharya,Bette Korber
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2002-06-28
卷期号:296 (5577): 2354-2360
被引量:798
标识
DOI:10.1126/science.1070441
摘要
Globally, human immunodeficiency virus–type 1 (HIV-1) is extraordinarily variable, and this diversity poses a major obstacle to AIDS vaccine development. Currently, candidate vaccines are derived from isolates, with the hope that they will be sufficiently cross-reactive to protect against circulating viruses. This may be overly optimistic, however, given that HIV-1 envelope proteins can differ in more than 30% of their amino acids. To contend with the diversity, country-specific vaccines are being considered, but evolutionary relationships may be more useful than regional considerations. Consensus or ancestor sequences could be used in vaccine design to minimize the genetic differences between vaccine strains and contemporary isolates, effectively reducing the extent of diversity by half.
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