Circulating brain-derived neurotrophic factor as a potential biomarker in stroke: a systematic review and meta-analysis

磁刺激 冲程(发动机) 医学 脑源性神经营养因子 神经营养因子 内科学 神经可塑性 萧条(经济学) 生物标志物 物理疗法 肿瘤科 神经心理学 物理医学与康复 生物信息学 认知 刺激 精神科 受体 机械工程 生物化学 化学 宏观经济学 生物 工程类 经济
作者
Helia Mojtabavi,Zoha Shaka,Sara Momtazmanesh,Atra Ajdari,Nima Rezaei
出处
期刊:Journal of Translational Medicine [BioMed Central]
卷期号:20 (1) 被引量:5
标识
DOI:10.1186/s12967-022-03312-y
摘要

Stroke, an acute cerebrovascular event, is a leading cause of disability, placing a significant psycho-socioeconomic burden worldwide. The adaptation and reorganization process following any neuronal damage is regarded as neuroplasticity. Among many factors believed to attribute to this process, Brain-derived Neurotrophic Factor (BDNF) is a neurotrophin coordinating neuroplasticity after various neurological disorders such as stroke.We conducted a systematic search in the main electronic medical databases in January 2021. Primarily we want to compare BDNF levels between patients with stroke and healthy controls (HC). Additional aims included investigation of (1) longitudinal changes in the BDNF levels post-stroke, (2) effects of physical training, (3) repeated transcranial magnetic stimulation (rTMS), and presence of depression on BDNF levels in patients with stroke.Among 6243 reviewed records from PubMed, Web of Science, and Scopus, 62 studies were eligible for inclusion in our systematic review. Subjects with stroke, n = 1856, showed lower BDNF levels compared to HC, n = 1191 (SMD [95%CI] = - 1.04 [- 1.49 to - 0.58]). No significant difference was detected in the level of BDNF through time points past stroke. BDNF levels were lower in the patients with depression compared to non-depressed subjects (SMD [95%CI] = - 0.60 [- 1.10 to - 0.10]). Physical training had an immediate positive effect on the BDNF levels and not statistically significant effect in the long term; SMD [95%CI] = 0.49 [0.09 to 0.88]) and SMD [95%CI] = 0.02 [- 0.43 to 0.47]). Lastly, rTMS showed no effect on the level of BDNF with 0.00 SMD.Our study confirms that stroke significantly decreases the level of BDNF in various domains such as cognition, affect, and motor function. As BDNF is the major representative of neuroplasticity within nervous system, it is believed that stroke has a significant impact on the CNS regeneration, which is permanent if left untreated. This effect is intensified with coexisting conditions such as depression which further decrease the BDNF level but the net impact yet needs to be discovered. We also conclude that exercise and some interventions such as different medications could effectively reverse the damage but further studies are crucial to reach the exact modality and dosage for their optimal effect.
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