医学
癸他滨
阿扎胞苷
威尼斯人
奥佐美星
米多司他林
低甲基化剂
骨髓增生异常综合症
氯法拉滨
药理学
肿瘤科
髓系白血病
内科学
作者
Hagop Kantarjian,Nicholas J Short,Courtney DiNardo,Eytan M Stein,Naval Daver,Alexander E Perl,Eunice S Wang,Andrew Wei,Martin Tallman
标识
DOI:10.1016/s2352-3026(21)00270-2
摘要
Research has resulted in regulatory approval of nine agents for acute myeloid leukaemia indications by the US Food and Drug Administration since 2017: the Bcl-2 inhibitor, venetoclax; two FLT3 inhibitors, midostaurin and gilteritinib; two IDH inhibitors, ivosidenib (IDH1 inhibitor) and enasidenib (IDH2 inhibitor); the anti-CD33 antibody-drug conjugate, gemtuzumab ozogamicin; the oral, poorly absorbable hypomethylating agent, azacitidine; the liposomal formulation of cytarabine and daunorubicin (5:1 ratio), CPX-351; and the hedgehog signalling pathway inhibitor, glasdegib. A 100% absorbable oral formulation of the hypomethylating agent decitabine was approved for the treatment of myelodysplastic syndrome and chronic myelomonocytic leukaemia, and might be used as an alternative to parenteral hypomethylating agents. Several of the approvals are as single-agent therapies or in specific combinations for narrow indications, thus offering poor treatment value. In this Review, we discuss ongoing research into combinations containing these commercially available targeted therapies for acute myeloid leukaemia.
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