Preparation and Utility of Platelet-Rich Plasma (PRP) for Facial Aging: A Comprehensive Review

Platelet-rich plasma (PRP) has gained tremendous traction for a broad variety of indications within regenerative medicine. Despite a lack of standardized literature assessing efficacy and best practice procedures for preparation, PRP has become increasingly utilized for cutaneous rejuvenation. In this review, we highlight the many variations that may affect the quality and effectiveness of PRP, while also outlining the highest quality evidence that exists for facial rejuvenation. In reviewing the use of PRP for this indication, most high-quality evidence suggests subtle to modest clinical improvement, with many studies demonstrating conflicting results. Additional high-quality investigative work with clearly delineated methodologies is needed in order to better understand the role of PRP.