膜
材料科学
再生(生物学)
阻隔膜
牙周纤维
静电纺丝
生物医学工程
牙周炎
组织工程
纳米技术
牙科
化学
复合材料
细胞生物学
聚合物
医学
生物化学
生物
作者
Amir Nasajpour,Sahar Ansari,Chiara Rinoldi,Afsaneh Shahrokhi Rad,Tara Aghaloo,Su Ryon Shin,Yogendra Kumar Mishra,Rainer Adelung,Wojciech Święszkowski,Nasim Annabi,Ali Khademhosseini,Alireza Moshaverinia,Ali Tamayol
标识
DOI:10.1002/adfm.201703437
摘要
Abstract Periodontitis is a prevalent chronic, destructive inflammatory disease affecting tooth‐supporting tissues in humans. Guided tissue regeneration strategies are widely utilized for periodontal tissue regeneration generally by using a periodontal membrane. The main role of these membranes is to establish a mechanical barrier that prevents the apical migration of the gingival epithelium and hence allowing the growth of periodontal ligament and bone tissue to selectively repopulate the root surface. Currently available membranes have limited bioactivity and regeneration potential. To address such challenges, an osteoconductive, antibacterial, and flexible poly(caprolactone) (PCL) composite membrane containing zinc oxide (ZnO) nanoparticles is developed. The membranes are fabricated through electrospinning of PCL and ZnO particles. The physical properties, mechanical characteristics, and in vitro degradation of the engineered membrane are studied in detail. Also, the osteoconductivity and antibacterial properties of the developed membrane are analyzed in vitro. Moreover, the functionality of the membrane is evaluated with a rat periodontal defect model. The results confirmed that the engineered membrane exerts both osteoconductive and antibacterial properties, demonstrating its great potential for periodontal tissue engineering.
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