活性氧
氧气张力
转录因子
氧气
细胞生物学
缺氧(环境)
NF-κB
缺氧诱导因子
基因表达
化学
基因
生物
生物化学
信号转导
有机化学
作者
Carine Michiels,Emmanuel Minet,Denis Mottet,Martine Raes
标识
DOI:10.1016/s0891-5849(02)01045-6
摘要
Aerobic life is dependent on molecular oxygen for ATP regeneration, but only possible in a narrow range of oxygen concentrations. Increased oxygen tension is toxic through the generation of reactive oxygen species (ROS), while a decrease in oxygen concentration impairs energy availability and, hence, cell viability. Cells have developed strategies to respond to changes in oxygen tension: specific systems detect excessive ROS and hypoxia, leading to the activation of specific transcription factors and expression of appropriate target genes. The aim of this review is to describe how hypoxia-inducible factor-1 (HIF-1) and nuclear factor-kappaB (NF-kappaB) are regulated and what could be the sensors to the changes in oxygen levels. Some of the physiological responses initiated by these transcription factors are also mentioned.
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