FYN公司
原癌基因酪氨酸蛋白激酶Src
脂肪生成
酪氨酸蛋白激酶
酪氨酸激酶
酪氨酸磷酸化
磷酸化
SH3域
细胞生物学
生物
受体酪氨酸激酶
激酶
SH2域
酪氨酸
信号转导
生物化学
间充质干细胞
作者
Yutong Sun,Yongchao Ma,Jianyun Huang,Krystina Y. Chen,Deirdre McGarrigle,Xin‐Yun Huang
出处
期刊:Biochemistry
[American Chemical Society]
日期:2005-10-13
卷期号:44 (44): 14455-14462
被引量:25
摘要
Src-family tyrosine kinases mediate many receptor signals to various biological responses. Here we investigate the requirement of Src-family tyrosine kinases in adipogenesis. The biochemical mechanism by which insulin induces adipogenesis, converting fibroblast cells to adipocytes, is not clear. We show that fibroblast cells deficient of three ubiquitously expressed Src-family members (Src, Yes, and Fyn), SYF cells, are refractory to hormonally induced fat accumulation. The defect is rescued by reintroduction of c-Src into SYF cells. Furthermore, Src-family tyrosine kinases are required in the early steps of insulin signaling; it is responsible for the tyrosine phosphorylation of adaptor protein c-Cbl. Deficiency of c-Cbl blocked adipogenesis. These genetic and biochemical data clearly demonstrate that Src-family tyrosine kinases serve as a critical signal relay, via phosphorylation of c-Cbl, for fat accumulation, and provide potential new strategies for treating obesity.
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