Canine diabetes mellitus: from phenotype to genotype

医学 单倍型 糖尿病 主要组织相容性复合体 等位基因 基因型 疾病 遗传倾向 繁殖 免疫学 人口 遗传学 免疫系统 生物 基因 内科学 内分泌学 环境卫生
作者
Briän Catchpole,L. J. Kennedy,Lucy J. Davison,William Ollier
出处
期刊:Journal of Small Animal Practice [Wiley]
卷期号:49 (1): 4-10 被引量:98
标识
DOI:10.1111/j.1748-5827.2007.00398.x
摘要

Breed differences in susceptibility to diabetes mellitus in dogs suggest an underlying genetic component to the pathogenesis of the disease. There is little evidence for an equivalent of human type 2 diabetes in dogs, and it has been proposed that canine diabetes is more comparable to the type 1 form of the disease. Certain immune response genes, particularly those encoding major histocompatibility complex molecules involved in antigen presentation, are important in determining susceptibility to human type 1 diabetes. We tested the hypothesis that canine major histocompatibility complex genes (known as the dog leucocyte antigen) are associated with diabetes in dogs. A total of 530 diabetic dogs and more than 1000 controls were typed for dog leucocyte antigen, and associations were found with three specific haplotypes. The DLA‐DRB1*009/DQA1*001/DQB1*008 haplotype shows the strongest association with diabetes in the UK dog population. This haplotype is common in diabetes‐prone breeds (Samoyed, cairn terrier and Tibetan terrier) but rare in diabetes‐resistant breeds (boxer, German shepherd dog and golden retriever), which could explain differences in the prevalence of diabetes in these different breeds. There is evidence that the DLA‐DQA1*001 allele is also associated with hypothyroidism, suggesting that this could represent a common susceptibility allele for canine immune‐mediated endocrinopathies.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
SYLH应助xzy998采纳,获得10
刚刚
Hina完成签到,获得积分10
1秒前
hahahahaha完成签到,获得积分10
3秒前
3秒前
Zero完成签到,获得积分10
4秒前
马騳骉发布了新的文献求助200
4秒前
4秒前
18°N天水色完成签到,获得积分10
5秒前
打打应助LeoXu采纳,获得10
5秒前
5秒前
5秒前
AoAoo发布了新的文献求助10
5秒前
踏实的大地应助栗园采纳,获得30
5秒前
等等完成签到,获得积分10
6秒前
某某完成签到,获得积分10
6秒前
小底完成签到,获得积分10
6秒前
6秒前
6秒前
6秒前
7秒前
linkin完成签到 ,获得积分10
7秒前
mirayq发布了新的文献求助10
8秒前
小张z完成签到,获得积分10
8秒前
松鼠非鼠完成签到 ,获得积分10
8秒前
科目三应助也行采纳,获得10
8秒前
Owen应助搞怪莫茗采纳,获得10
8秒前
小豆包发布了新的文献求助10
9秒前
哆1627_完成签到,获得积分10
9秒前
9秒前
10秒前
10秒前
kathy发布了新的文献求助10
10秒前
manman发布了新的文献求助10
11秒前
SYLH应助xzy998采纳,获得10
11秒前
豪厉害完成签到,获得积分10
11秒前
仲半邪完成签到,获得积分10
11秒前
苏博儿发布了新的文献求助10
11秒前
叼面包的数学狗完成签到 ,获得积分10
11秒前
yao完成签到,获得积分10
12秒前
量子星尘发布了新的文献求助10
12秒前
高分求助中
The Mother of All Tableaux Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 2400
Ophthalmic Equipment Market by Devices(surgical: vitreorentinal,IOLs,OVDs,contact lens,RGP lens,backflush,diagnostic&monitoring:OCT,actorefractor,keratometer,tonometer,ophthalmoscpe,OVD), End User,Buying Criteria-Global Forecast to2029 2000
Optimal Transport: A Comprehensive Introduction to Modeling, Analysis, Simulation, Applications 800
Official Methods of Analysis of AOAC INTERNATIONAL 600
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 588
A new approach to the extrapolation of accelerated life test data 500
T/CIET 1202-2025 可吸收再生氧化纤维素止血材料 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3953623
求助须知:如何正确求助?哪些是违规求助? 3499390
关于积分的说明 11095224
捐赠科研通 3229945
什么是DOI,文献DOI怎么找? 1785807
邀请新用户注册赠送积分活动 869573
科研通“疑难数据库(出版商)”最低求助积分说明 801479