脂肪因子
脂联素
脂肪组织
炎症
内分泌学
内科学
抵抗素
瘦素
白色脂肪组织
切梅林
肿瘤坏死因子α
医学
生物
免疫学
胰岛素抵抗
糖尿病
肥胖
作者
Paul Trayhurn,I. Stuart Wood
出处
期刊:Biochemical Society Transactions
[Portland Press]
日期:2005-10-26
卷期号:33 (5): 1078-1081
被引量:566
摘要
White adipose tissue (WAT) is a major endocrine and secretory organ, which releases a wide range of protein signals and factors termed adipokines. A number of adipokines, including leptin, adiponectin, tumour necrosis factor α, IL-1β (interleukin 1β), IL-6, monocyte chemotactic protein-1, macrophage migration inhibitory factor, nerve growth factor, vascular endothelial growth factor, plasminogen activator inhibitor 1 and haptoglobin, are linked to inflammation and the inflammatory response. Obesity is characterized by a state of chronic mild inflammation, with raised circulating levels of inflammatory markers and the expression and release of inflammation-related adipokines generally rises as adipose tissue expands (adiponectin, which has anti-inflammatory action is an exception). The elevated production of inflammation-related adipokines is increasingly considered to be important in the development of diseases linked to obesity, particularly Type II diabetes and the metabolic syndrome. WAT is involved in extensive cross-talk with other organs and multiple metabolic systems through the various adipokines.
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