细胞色素P450
异型生物质的
机制(生物学)
细胞色素
药物代谢
生物
新陈代谢
酶
计算生物学
生物化学
认识论
哲学
作者
Paul R. Ortiz de Montellano
出处
期刊:Medicinal chemistry
[OMICS Publishing Group]
日期:2018-01-01
卷期号:08 (03)
被引量:36
标识
DOI:10.4172/2161-0444.1000495
摘要
1-Aminobenzotriazole (1-ABT) is a pan-specific, mechanism-based inactivator of the xenobiotic metabolizing forms of cytochrome P450 in animals, plants, insects, and microorganisms. It has been widely used to investigate the biological roles of cytochrome P450 enzymes, their participation in the metabolism of both endobiotics and xenobiotics, and their contributions to the metabolism-dependent toxicity of drugs and chemicals. This review is a comprehensive evaluation of the chemistry, discovery, and use of 1-aminobenzotriazole in these contexts from its introduction in 1981 to the present.
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