A Review on Vitamin E Natural Analogues and on the Design of Synthetic Vitamin E Derivatives as Cytoprotective Agents
维生素
维生素C
维生素D与神经学
生物化学
作者
Panagiotis Theodosis-Nobelos,Georgios Papagiouvannis,Eleni A. Rekka
出处
期刊:Mini-reviews in Medicinal Chemistry [Bentham Science] 日期:2021-01-01卷期号:21 (1): 10-22被引量:8
标识
DOI:10.2174/1389557520666200807132617
摘要
Vitamin E, essential for human health, is widely used worldwide for therapeutic or dietary reasons. The differences in the metabolism and excretion of the multiple vitamin E forms are presented in this review. The important steps that influence the kinetics of each form and the distribution and processing of vitamin E forms by the liver are considered. The antioxidant as well as non-antioxidant properties of vitamin E forms are discussed. Finally, synthetic tocopherol and trolox derivatives, based on the design of multitarget directed compounds, are reviewed. It is demonstrated that selected derivatization of vitamin E or trolox structures can produce improved antioxidants, agents against cancer, cardiovascular and neurodegenerative disorders.