阿维菌素
纳米载体
控制释放
纳米颗粒
药物输送
纳米技术
共价键
杀虫剂
材料科学
组合化学
介孔材料
化学
介孔二氧化硅
医学
生物
催化作用
有机化学
解剖
农学
作者
You Liang,Yunhao Gao,Weichen Wang,Hongqiang Dong,Rong Tang,Jiale Yang,Junfan Niu,Zhiyuan Zhou,Jiang Na,Yongsong Cao
标识
DOI:10.1016/j.jhazmat.2020.122075
摘要
It is highly desirable to construct stimuli-responsive nanocarriers for improving pesticides targeting and preventing the pesticides premature release. In this work, a novel redox and α-amylase dual stimuli-responsive pesticide delivery system was established by bonding functionalized starch with biodegradable disulfide-bond-bridged mesoporous silica nanoparticles which loaded with avermectin ([email protected] nanoparticles). The results demonstrated that the loading capacity of [email protected] nanoparticles for avermectin was approximately 9.3 %. The starch attached covalently on the mesoporous silica nanoparticles could protect avermectin from photodegradation and prevent premature release of active ingredient. Meanwhile, the coated starch and disulfide-bridged structure of nanoparticles could be decomposed and consequently release of the avermectin on demand when nanoparticles were metabolized by glutathione and α-amylase in insects. The bioactivity survey confirmed that [email protected] nanoparticles had a longer duration in controlling Plutella xylostella larvae compared to avermectin emulsifiable concentrate. In consideration of the superior insecticidal activity and free of toxic organic solvent, this target-specific pesticide release system has promising potential in pest management.
科研通智能强力驱动
Strongly Powered by AbleSci AI