亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Effects of Glucocorticoids on Postoperative Delirium in Adult Patients Undergoing Cardiac Surgery: A Systematic Review and Meta-analysis

医学 谵妄 心脏外科 荟萃分析 内科学 麻醉 外科 重症监护医学
作者
Wenxue Liu,Yali Wang,Junxia Wang,Jian Qing Shi,Jun Pan,Dongjin Wang
出处
期刊:Clinical Therapeutics [Elsevier BV]
卷期号:43 (9): 1608-1621 被引量:7
标识
DOI:10.1016/j.clinthera.2021.07.021
摘要

Purpose Delirium is a common neurologic complication after cardiac surgery and is associated with a poor prognosis. Several studies have explored the effects of glucocorticoids on postoperative delirium (POD). However, conclusion have been inconsistent. The purpose of this systematic review and meta-analysis is to evaluate the effects of glucocorticoids on POD in adult patients undergoing cardiac surgery. Methods A systematic literature search was conducted using PubMed/MEDLINE, Embase, Cochrane Library/Central, and Web of Science from inception to January 28, 2021. Randomized controlled trials evaluating the effects of perioperative glucocorticoids administration on the incidence of POD in adults (≥18 years of age) undergoing cardiac surgery were included. The primary outcome of incidence of POD was assessed using the risk ratio (RR) with a fixed-effects model. Secondary analyses included the severity or duration of delirium, mortality at 30 days, length of hospital and intensive care unit (ICU) stay, duration of mechanical ventilatory support, the incidence of myocardial injury, new atrial fibrillation, renal and respiratory failure, postoperative infection and stroke, and the level of glucose and inflammatory factors. Findings A total 4 trials (n = 8448 patients) were included. Glucocorticoids did not significantly reduce the incidence of POD (RR = 0.99; 95% CI, 0.86–1.14) but increased the risk of myocardial injury (RR = 1.22; 95% CI, 1.08–1.38), decreased the duration of mechanical ventilatory support (mean difference, −0.83; 95% CI, −1.32 to −0.34), and led to a tendency toward short length of ICU stay (mean difference, −0.22; 95% CI, −0.47 to −0.03). No significant differences were observed in other secondary outcomes. Implications The perioperative administration of glucocorticoids did not reduce the incidence of POD in adult patients undergoing cardiac surgery but might be associated with shorter duration of mechanical ventilatory support and a tendency toward a shorter length of ICU stay. Furthermore, we found that glucocorticoids may increase the rate of myocardial injury but have no effects on other clinical outcomes. International Prospective Register of Systematic Reviews identifier: CRD42021233458.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
binyao2024完成签到,获得积分10
1分钟前
光亮静槐完成签到 ,获得积分10
1分钟前
lrl350495627发布了新的文献求助10
2分钟前
lrl350495627完成签到,获得积分10
2分钟前
GingerF应助科研通管家采纳,获得50
2分钟前
FashionBoy应助andrele采纳,获得10
2分钟前
3分钟前
自然芷文发布了新的文献求助10
3分钟前
3分钟前
我是老大应助自然芷文采纳,获得10
4分钟前
iNk应助吗喽采纳,获得20
4分钟前
研友_VZG7GZ应助科研通管家采纳,获得10
4分钟前
打打应助科研通管家采纳,获得10
4分钟前
Charlie完成签到 ,获得积分10
4分钟前
CodeCraft应助Benhnhk21采纳,获得30
4分钟前
5分钟前
Benhnhk21发布了新的文献求助30
5分钟前
科研通AI2S应助科研通管家采纳,获得10
6分钟前
村口的帅老头完成签到 ,获得积分0
6分钟前
6分钟前
gincle完成签到 ,获得积分10
7分钟前
7分钟前
andrele发布了新的文献求助10
7分钟前
7分钟前
7分钟前
积极的台灯完成签到,获得积分10
7分钟前
紫荆完成签到,获得积分10
8分钟前
Johnson完成签到 ,获得积分10
8分钟前
李健应助科研通管家采纳,获得10
8分钟前
Benhnhk21发布了新的文献求助10
8分钟前
wanci应助淡然绝山采纳,获得10
8分钟前
9分钟前
wkjfh应助YaoQi采纳,获得10
9分钟前
dyuguo3完成签到 ,获得积分10
9分钟前
某某某发布了新的文献求助10
10分钟前
10分钟前
淡然绝山发布了新的文献求助10
10分钟前
Benhnhk21完成签到,获得积分10
10分钟前
JamesPei应助andrele采纳,获得10
10分钟前
完美世界应助xiongdi521采纳,获得10
11分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990181
求助须知:如何正确求助?哪些是违规求助? 3532136
关于积分的说明 11256472
捐赠科研通 3271042
什么是DOI,文献DOI怎么找? 1805190
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809234