In this paper, we propose a novel group variance inflation factor (VIF) regression model for tackling large data sets where data follows a grouped structure. Unlike classical penalized methods, this approach can perform group variable selection in a sparse model, which is quite different from the classical penalized methods. We further adapt the proposed method associated with a two-stage procedure for detecting multiple change-point in linear models. We carry out extensive simulation studies to show that the proposed group variable selection and change-point detection methods are stable and efficient. Finally, we provide two real data examples, including a body fat data set and an air pollution data set, to illustrate the performance of our algorithms in group selection and change-point detection.