Reducing dose to rectum by placement of a rectum-emptying tube in cervical cancer patients treated with brachytherapy

直肠 医学 近距离放射治疗 核医学 子宫颈 放射科 宫颈癌 放射治疗 外科 癌症 内科学
作者
Marjorie Ferré,Leonel Varela Cagetti,Christophe Zemmour,Marguerite Tyran,Pierre Fau,Cyrus Chargari,Agnès Tallet,Laurence Gonzague,Pierre Annède
出处
期刊:Brachytherapy [Elsevier BV]
卷期号:20 (4): 748-754 被引量:3
标识
DOI:10.1016/j.brachy.2021.03.008
摘要

PURPOSE Only scarce data are available on the possibility to reduce rectal dose by controlling rectum filling before HDR (high dose rate) IGABT (image-guided adaptive brachytherapy) in LACC (locally advanced cervical carcinoma) patients. We compared dosimetric outcomes before and after the evacuation of gasses using a rectum emptying tube. METHODS AND MATERIAL Sixty CT (computed tomography) scans from 30 consecutive patients with cancer of the cervix undergoing HDR IGABT after EBRT were reviewed. Patients who underwent at least one gas evacuation were included in the analysis. The three-dimensional dosimetric data of the dosimetric plan performed before and after gas evacuation were compared. Primary endpoint was the difference between D2cc of the rectum before and after the procedure. Expected probability of grade 2–4 overall rectum morbidity was assessed using a probit model from the prospective multicenter EMBRACE study. RESULTS Thirty five (58.3%) CT scans from 23 patients (76.7%) requiring gas evacuation were analysed. The mean rectum volume, before and after gas evacuation, was 123.1 cc (sd, ± 60.4) and 66.4 cc (sd, ± 34.8), respectively. For each patient, the volume of the rectum after gas evacuation was lower than before. No major complication occurred during and after the procedure. After gas evacuation, a significant reduction in rectal dose per fraction was observed, on average -4.3 Gy (-38.4%, p < 0.001) for D0.1cc and -1.9 Gy (-30.6%, p < 0.001) for D2cc. Estimated mean probability to develop a grade 2–4 rectum morbidity was significantly lower after gas evacuation, 6.9% (sd,± 1.94) versus 9.5% (sd,± 3.17), p < 0.001. CONCLUSION Gas evacuation using a rectal emptying tube in selected LACC patients treated with HDR BT after chemoradiotherapy, allowed a substantial reduction in the dose to the rectum. Such procedure could be of particular interest when a dose escalation strategy is being considered.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
CipherSage应助义气如萱采纳,获得10
刚刚
zty发布了新的文献求助30
刚刚
SS发布了新的文献求助10
刚刚
戴岱发布了新的文献求助10
2秒前
4秒前
量子星尘发布了新的文献求助10
6秒前
7秒前
张大英发布了新的文献求助10
9秒前
马er完成签到,获得积分20
9秒前
奮斗完成签到,获得积分10
9秒前
戴岱完成签到,获得积分10
10秒前
哈哈鹿发布了新的文献求助10
11秒前
11秒前
黎明森完成签到,获得积分10
11秒前
Monica应助朴素若枫采纳,获得30
12秒前
13秒前
科研通AI5应助科研通管家采纳,获得10
13秒前
SYLH应助科研通管家采纳,获得30
13秒前
13秒前
czh应助科研通管家采纳,获得10
13秒前
科研通AI2S应助科研通管家采纳,获得10
13秒前
13秒前
今后应助科研通管家采纳,获得10
13秒前
顾矜应助科研通管家采纳,获得10
13秒前
13秒前
丘比特应助科研通管家采纳,获得10
13秒前
赘婿应助科研通管家采纳,获得10
13秒前
13秒前
13秒前
13秒前
王羊补牢发布了新的文献求助10
16秒前
布施德完成签到 ,获得积分10
17秒前
Zzz完成签到,获得积分10
18秒前
呆萌板凳完成签到,获得积分20
20秒前
21秒前
22秒前
哈哈鹿完成签到,获得积分10
22秒前
SS完成签到,获得积分20
23秒前
华仔应助t团子采纳,获得10
26秒前
27秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989242
求助须知:如何正确求助?哪些是违规求助? 3531393
关于积分的说明 11253753
捐赠科研通 3270010
什么是DOI,文献DOI怎么找? 1804868
邀请新用户注册赠送积分活动 882084
科研通“疑难数据库(出版商)”最低求助积分说明 809136