人参
酪氨酸酶
化学
体外
皮肤美白
抗氧化剂
体内
生物化学
五加科
食品科学
细胞凋亡
枸杞
活性成分
传统医学
药理学
生物
酶
医学
替代医学
生物技术
病理
作者
Yulin Dai,Di Yang,Lai-Hui Song,Hongmei Yang,Jinlong Yu,Fei Zheng,Yanpeng Hao,Changbao Chen,En-Peng Wang
摘要
To find new anti-UV and whitening agents, 21 fractions isolated from three preparations of ginseng (white, red, and black ginseng) were screened, and their antioxidant effects on AAPH- or H2O2-induced damage were investigated. Furthermore, the protective effect against UV-mediated apoptosis and the tyrosinase inhibitory activity of the targeted fractions were evaluated in vitro and in a zebrafish model. Among all fractions, F10 from white ginseng was selected as having the strongest anti-UV and antimelanogenesis activities. This fraction exhibited excellent inhibitory effects on the pigmentation of zebrafish, which may be due to its potential tyrosinase inhibitory activity. Additionally, the chemical composition of F10 was evaluated by UPLC-MS and NMR instruments. The results indicated that F10 had a carbohydrate content of more than 76%, and the weight-average molecular weight was approximately 239 Da. Disaccharide sucrose was the main active compound in F10. These results suggest that F10 could be used as an ingredient for whitening cosmetics and regarded as an anti-UV filter in the future.
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