医学
冠状动脉疾病
病理生理学
心脏病学
心绞痛
心力衰竭
内科学
缺血
内皮功能障碍
微循环
疾病
心肌梗塞
作者
Marco Giuseppe Del Buono,Rocco A. Montone,Massimiliano Camilli,Salvatore Carbone,Jagat Narula,Carl J. Lavie,Giampaolo Niccoli,Filippo Crea
标识
DOI:10.1016/j.jacc.2021.07.042
摘要
Coronary microvascular dysfunction (CMD) encompasses several pathogenetic mechanisms involving coronary microcirculation and plays a major role in determining myocardial ischemia in patients with angina without obstructive coronary artery disease, as well as in several other conditions, including obstructive coronary artery disease, nonischemic cardiomyopathies, takotsubo syndrome, and heart failure, especially the phenotype associated with preserved ejection fraction. Unfortunately, despite the identified pathophysiological and prognostic role of CMD in several conditions, to date, there is no specific treatment for CMD. Due to the emerging role of CMD as common denominator in different clinical phenotypes, additional research in this area is warranted to provide personalized treatments in this "garden variety" of patients. The purpose of this review is to describe the pathophysiological mechanisms of CMD and its mechanistic and prognostic role across different cardiovascular diseases. We will also discuss diagnostic modalities and the potential therapeutic strategies resulting from recent clinical studies.
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