Differentiation of clinical patterns and survival outcomes of hepatocellular carcinoma on hepatitis B and nonalcoholic fatty liver disease

医学 肝细胞癌 内科学 非酒精性脂肪肝 乙型肝炎表面抗原 胃肠病学 肝硬化 乙型肝炎 乙型肝炎病毒 脂肪肝 肝功能 肝病 肝癌 体质指数 疾病 免疫学 病毒
作者
Bou-Zenn Lin,Tsung-Jung Lin,Chih‐Lin Lin,Li-Ying Liao,Ting-An Chang,Buo‐Jia Lu,Kuan-Yang Chen
出处
期刊:Journal of The Chinese Medical Association [Lippincott Williams & Wilkins]
卷期号:84 (6): 606-613 被引量:15
标识
DOI:10.1097/jcma.0000000000000530
摘要

The main etiologies of hepatocellular carcinoma (HCC) were often hepatitis B virus (HBV) or C and alcohol, rarely autoimmune and biliary diseases. Nonalcoholic fatty liver disease (NAFLD) has been an emerging role that could lead to chronic liver disease, nonalcoholic steatohepatitis, cirrhosis, and eventually HCC in recent years. The aim of our study is to investigate and compare the clinical features of HCC in patients with NAFLD and HBV, including age, gender, cirrhosis, liver function tests, largest tumor size, and cancer stage at the time of diagnosis. The survival outcome was compared between the two groups and the significant predictors of mortality were also analyzed in all patients with HCC.Most patients with HCC were recruited from the database of Cancer Registries in Taipei City Hospital, Ren-Ai Branch, from 2011 to 2017; and the other patients consecutively from the HCC multidisciplinary conference between January 2018 and December 2019. NAFLD was defined as nonviral hepatitis B (negative HBsAg and either positive anti-HBs or negative anti-HBc), nonviral hepatitis C (negative antihepatitis C virus [HCV]), nonalcoholic (alcohol consumption of <30 g/d for men and <20 g/d for women) liver disease, or present or past histological or ultrasonographic evidence of fatty liver. Totally, 23 NAFLD-related and 156 HBV-related HCC patients were enrolled in our study for further analysis.NAFLD-related HCC patients were significantly older (median age: 70.0 [61.0-79.0] years vs. 63.0 [56.0-72.0] years, p = 0.012) and heavier (median body mass index [BMI]: 26.6 [24.2-30] kg/m2 vs. 24.8 [22.0-27.1] kg/m2, p = 0.044) than those with HBV-related HCC. They were also more susceptible to diabetes mellitus (DM), and 60.9% (14 of 23) of them had this comorbidity compared with 29.5% (46 of 156) of those with HBV-related HCC (p = 0.003). Only 34.8% (8 of 23) and 71.2% (111 of 156) of patients with NAFLD- and HBV-related HCC were cirrhotic, respectively (p = 0.001). However, gender, tobacco use, international normalized ratio, albumin, creatinine, and cholesterol levels were not significantly different between the two groups. Tumor characteristics such as the Barcelona clinic liver cancer stage, largest tumor size, tumor number, extrahepatic metastasis, and treatment modalities had no significant difference between such groups.According to the Kaplan-Meier method analysis, the overall survival was not significantly different between these two patient groups (log-rank test, p = 0.101). To evaluate which patient group would lead to poor prognosis, we analyzed the survival of all patients through multivariate Cox proportional hazard regression after controlling other factors that may influence the hazard ratio. The analysis revealed that NAFLD and HBV infection as the cause of HCC are not risk factors of poor prognosis.In conclusion, our study showed NAFLD-related HCC patients were older, heavier, and more had DM than HBV-related. In addition, more NAFLD-related HCC patients were noncirrhotic than HBV-related. The survival rate was similar between NAFLD and HBV-related HCC patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
FashionBoy应助潇湘雪月采纳,获得10
1秒前
传奇3应助leanne采纳,获得10
1秒前
大模型应助Heartlark采纳,获得10
3秒前
5秒前
moxi摩西完成签到,获得积分10
5秒前
卷卷完成签到,获得积分10
7秒前
时笙发布了新的文献求助10
8秒前
8秒前
pterion完成签到,获得积分10
8秒前
8秒前
10秒前
哒哒完成签到,获得积分10
12秒前
12秒前
循环发布了新的文献求助10
12秒前
幽默毛衣发布了新的文献求助10
15秒前
17秒前
循环完成签到,获得积分10
17秒前
leanne发布了新的文献求助10
17秒前
18秒前
量子星尘发布了新的文献求助10
18秒前
19秒前
19秒前
开灯人和关灯人完成签到,获得积分20
20秒前
Stardust发布了新的文献求助10
21秒前
22秒前
FashionBoy应助爱笑晓曼采纳,获得10
23秒前
张雯思发布了新的文献求助10
24秒前
Priority完成签到,获得积分10
25秒前
光热效应发布了新的文献求助30
25秒前
风之星给风之星的求助进行了留言
25秒前
25秒前
ASH发布了新的文献求助10
25秒前
OxO完成签到,获得积分10
25秒前
26秒前
搜集达人应助快乐一江采纳,获得10
26秒前
27秒前
leanne完成签到,获得积分20
28秒前
幽默毛衣完成签到,获得积分10
29秒前
晨曦完成签到,获得积分10
29秒前
延文星发布了新的文献求助10
31秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989390
求助须知:如何正确求助?哪些是违规求助? 3531487
关于积分的说明 11254109
捐赠科研通 3270153
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809174