Intracellular Zn2+ promotes extracellular matrix remodeling in dexamethasone-treated trabecular meshwork

Our study explores zinc’s pivotal role in mitigating extracellular matrix dysregulation in the trabecular meshwork and glucocorticoid-induced ocular hypertension. We found that in human trabecular meshwork cells treated with dexamethasone, intracellular Zn 2+ significantly decreased, accompanied by impaired extracellular Zn 2+ uptake. Zinc supplementation rescues visual function by modulating extracellular matrix proteins and lowering intraocular pressure, offering a direction for further exploration in glaucoma management.