Global longitudinal strain as a predictor of risk in patients with heart failure with preserved ejection fraction: A deserved role?

European Journal of Heart FailureEarly View Invited Editorial Global longitudinal strain as a predictor of risk in patients with heart failure with preserved ejection fraction: A deserved role? Francois Deharo, Francois Deharo Cardiology Department, Guy's and St Thomas' National Health Service Foundation Trust, London, UKSearch for more papers by this authorJulia Grapsa, Corresponding Author Julia Grapsa [email protected] Cardiology Department, Guy's and St Thomas' National Health Service Foundation Trust, London, UK Corresponding author. St Thomas' National Health Service Foundation Trust, Westminster Bridge Rd, London SE1 7EH, UK. Email: [email protected]Search for more papers by this author Francois Deharo, Francois Deharo Cardiology Department, Guy's and St Thomas' National Health Service Foundation Trust, London, UKSearch for more papers by this authorJulia Grapsa, Corresponding Author Julia Grapsa [email protected] Cardiology Department, Guy's and St Thomas' National Health Service Foundation Trust, London, UK Corresponding author. St Thomas' National Health Service Foundation Trust, Westminster Bridge Rd, London SE1 7EH, UK. Email: [email protected]Search for more papers by this author First published: 25 March 2024 https://doi.org/10.1002/ejhf.3211 The opinions expressed in this article are not necessarily those of the Editors of the European Journal of Heart Failure or of the European Society of Cardiology. doi: 10.1002/ejhf.3167. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). With the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 2022; 24: 4–131. https://doi.org/10.1002/ejhf.2333 10.1002/ejhf.2333 PubMedWeb of Science®Google Scholar 2Stoicescu L, Crişan D, Morgovan C, Avram L, Ghibu S. Heart failure with preserved ejection fraction: The pathophysiological mechanisms behind the clinical phenotypes and the therapeutic approach. Int J Mol Sci 2024; 25:794. https://doi.org/10.3390/ijms25020794 10.3390/ijms25020794 CASPubMedWeb of Science®Google Scholar 3Shah AM, Claggett B, Sweitzer NK, Shah SJ, Anand IS, Liu L, et al. Prognostic importance of impaired systolic function in heart failure with preserved ejection fraction and the impact of spironolactone. Circulation 2015; 132: 402–414. https://doi.org/10.1161/CIRCULATIONAHA.115.015884 10.1161/CIRCULATIONAHA.115.015884 CASPubMedWeb of Science®Google Scholar 4Buggey J, Alenezi F, Yoon HJ, Phelan M, DeVore AD, Khouri MG, et al. Left ventricular global longitudinal strain in patients with heart failure with preserved ejection fraction: Outcomes following an acute heart failure hospitalization. ESC Heart Fail 2017; 4: 432–439. https://doi.org/10.1002/ehf2.12159 10.1002/ehf2.12159 CASPubMedWeb of Science®Google Scholar 5Pellicori P, Kallvikbacka-Bennett A, Khaleva O, Carubelli V, Costanzo P, Castiello T, et al. Global longitudinal strain in patients with suspected heart failure and a normal ejection fraction: Does it improve diagnosis and risk stratification? Int J Cardiovasc Imaging 2014; 30: 69–79. https://doi.org/10.1007/s10554-013-0310-y 10.1007/s10554-013-0310-y PubMedWeb of Science®Google Scholar 6Minamisawa M, Inciardi RM, Claggett B, Cikes M, Liu L, Prasad N, et al. Clinical implications of subclinical left ventricular dysfunction in heart failure with preserved ejection fraction: The PARAGON-HF study. Eur J Heart Fail. https://doi.org/10.1002/ejhf.3167 Published online ahead of print 18/02/24. 10.1002/ejhf.3167 Web of Science®Google Scholar 7Shah AM, Cikes M, Prasad N, Li G, Getchevski S, Claggett B, et al.; PARAGON-HF Investigators. Echocardiographic features of patients with heart failure and preserved left ventricular ejection fraction. J Am Coll Cardiol 2019; 74: 2858–2873. https://doi.org/10.1016/j.jacc.2019.09.063 10.1016/j.jacc.2019.09.063 CASPubMedWeb of Science®Google Scholar 8Solomon SD, McMurray JJV, Anand IS, Ge J, Lam CSP, Maggioni AP, et al.; PARAGON-HF Investigators and Committees. Angiotensin-neprilysin inhibition in heart failure with preserved ejection fraction. N Engl J Med 2019; 381: 1609–1620. https://doi.org/10.1056/NEJMoa1908655 10.1056/NEJMoa1908655 CASPubMedWeb of Science®Google Scholar 9Rahimi K, Bennett D, Conrad N, Williams TM, Basu J, Dwight J, et al. Risk prediction in patients with heart failure: A systematic review and analysis. JACC Heart Fail 2014; 2: 440–446. https://doi.org/10.1016/j.jchf.2014.04.008 10.1016/j.jchf.2014.04.008 PubMedWeb of Science®Google Scholar 10Pieske B, Tschöpe C, De Boer RA, Fraser AG, Anker SD, Donal E, et al. How to diagnose heart failure with preserved ejection fraction: The HFA-PEFF diagnostic algorithm: A consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur Heart J 2019; 40: 3297–3317. https://doi.org/10.1093/eurheartj/ehz641 10.1093/eurheartj/ehz641 PubMedWeb of Science®Google Scholar 11Li P, Zhao H, Zhang J, Ning Y, Tu Y, Xu D, et al. Similarities and differences between HFmrEF and HFpEF. Front Cardiovasc Med 2021; 8:678614. https://doi.org/10.3389/fcvm.2021.678614 10.3389/fcvm.2021.678614 CASPubMedWeb of Science®Google Scholar 12Borlaug BA. The pathophysiology of heart failure with preserved ejection fraction. Nat Rev Cardiol 2014; 11: 507–515. https://doi.org/10.1038/nrcardio.2014.83 10.1038/nrcardio.2014.83 CASPubMedWeb of Science®Google Scholar 13Crea F, Bairey Merz CN, Beltrame JF, Kaski JC, Ogawa H, Ong P, et al.; Coronary Vasomotion Disorders International Study Group (COVADIS). The parallel tales of microvascular angina and heart failure with preserved ejection fraction: A paradigm shift. Eur Heart J 2017; 38: 473–477. https://doi.org/10.1093/eurheartj/ehw461 10.1093/eurheartj/ehw461 CASPubMedWeb of Science®Google Scholar 14Bilak JM, Alam U, Miller CA, McCann GP, Arnold JR, Kanagala P. Microvascular dysfunction in heart failure with preserved ejection fraction: Pathophysiology, assessment, prevalence and prognosis. Card Fail Rev 2022; 8:e24. https://doi.org/10.15420/cfr.2022.12 10.15420/cfr.2022.12 PubMedGoogle Scholar 15Woolley RJ, Ceelen D, Ouwerkerk W, Tromp J, Figarska SM, Anker SD, et al. Machine learning based on biomarker profiles identifies distinct subgroups of heart failure with preserved ejection fraction. Eur J Heart Fail 2021; 23: 983–991. https://doi.org/10.1002/ejhf.2144 10.1002/ejhf.2144 CASPubMedWeb of Science®Google Scholar Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation