Hair Follicles as a Critical Model for Monitoring the Circadian Clock

昼夜节律 时钟 时辰疗法(睡眠期) 生物钟 生物 细菌昼夜节律 神经科学 内分泌学 内科学 医学
作者
Li-Ping Liu,Meng-Huan Li,Yun‐Wen Zheng
出处
期刊:International Journal of Molecular Sciences [MDPI AG]
卷期号:24 (3): 2407-2407 被引量:5
标识
DOI:10.3390/ijms24032407
摘要

Clock (circadian) genes are heterogeneously expressed in hair follicles (HFs). The genes can be modulated by both the central circadian system and some extrinsic factors, such as light and thyroid hormones. These circadian genes participate in the regulation of several physiological processes of HFs, including hair growth and pigmentation. On the other hand, because peripheral circadian genes are synchronized with the central clock, HFs could provide a noninvasive and practical method for monitoring and evaluating multiple circadian-rhythm-related conditions and disorders among humans, including day and night shifts, sleep–wake disorders, physical activities, energy metabolism, and aging. However, due to the complexity of circadian biology, understanding how intrinsic oscillation operates using peripheral tissues only may be insufficient. Combining HF sampling with multidimensional assays such as detection of body temperature, blood samples, or certain validated questionnaires may be helpful in improving HF applications. Thus, HFs can serve as a critical model for monitoring the circadian clock and can help provide an understanding of the potential mechanisms of circadian-rhythm-related conditions; furthermore, chronotherapy could support personalized treatment scheduling based on the gene expression profile expressed in HFs.
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