生物
转录组
核糖核酸
计算生物学
RNA剪接
聚腺苷酸
基因表达谱
癌变
选择性拼接
基因
基因表达
小RNA
遗传学
信使核糖核酸
作者
Zhiliang Bai,Dingyao Zhang,Yan Gao,Bo Tao,Shuozhen Bao,Archibald Enninful,Daiwei Zhang,Graham Su,Xiaolong Tian,Ningning Zhang,Yang Xiao,Yang Liu,Mark Gerstein,Mingyao Li,Yi Xing,Jun Lü,Mina L. Xu,Rong Fan
标识
DOI:10.1101/2024.02.06.579143
摘要
Spatial transcriptomics has emerged as a powerful tool for dissecting spatial cellular heterogeneity but as of today is largely limited to gene expression analysis. Yet, the life of RNA molecules is multifaceted and dynamic, requiring spatial profiling of different RNA species throughout the life cycle to delve into the intricate RNA biology in complex tissues. Human disease-relevant tissues are commonly preserved as formalin-fixed and paraffin-embedded (FFPE) blocks, representing an important resource for human tissue specimens. The capability to spatially explore RNA biology in FFPE tissues holds transformative potential for human biology research and clinical histopathology. Here, we present Patho-DBiT combining
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