化学
席夫碱
插层(化学)
DNA
共价键
金属
加合物
荧光
组合化学
碱基对
沟槽(工程)
高分子化学
立体化学
无机化学
有机化学
生物化学
物理
材料科学
量子力学
冶金
作者
Mansi,Charu Bhutani,Pankaj Khanna,Manisha Jain,Sangeeta Talwar,Shilpa Yadav,Leena Khanna
标识
DOI:10.2174/0113852728277676231024062455
摘要
Abstract: Schiff bases are dynamic organic compounds of bioactive importance, acting as flexible ligands and can form complexes with metals. Schiff bases along with their metal complexes have shown a large affinity towards DNA, which is one of the main targets of chemotherapeutics. DNA can join hands with these motifs in multiple ways, like covalent (crosslinking adducts) and non-covalent (intercalative or groove binding via electrostatic) interactions. Besides, the binding ability and types vary with the metals involved in Schiff base metal complexes. Thus, this review aims to describe significant recent reports of Schiff bases and their metal complexes capable of binding with DNA to evaluate the superlative DNA binders, type of association, and best metal-Schiff base combinations. Among the experimental techniques employed in revealing these interactions, noteworthy UV absorption and fluorescence spectroscopy studies have been discussed for the assessment of various types of bindings as intercalation or groove type.
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