Difference between treatment-resistant schizophrenia and clozapine-resistant schizophrenia

We read the impressive review article "Clozapine resistant schizophrenia: Newer avenues of management" with great enthusiasm and appreciation. The author believes that preventing clozapine resistance from developing may be the most effective treatment strategy for patients with clozapine-resistant schizophrenia (CRS), and optimizing clozapine treatment is a key component. Disentangling the differences between treatment-resistant schizophrenia and CRS is important for studies addressing treatment strategies for these difficult-to-treat populations.