医学
类风湿性关节炎
风湿病
类风湿因子
血清学
生物标志物
痹症科
内科学
免疫学
物理疗法
抗体
生物化学
化学
作者
Vineeta A Ramnauth,Patrick Rooney
出处
期刊:Cureus
[Cureus, Inc.]
日期:2023-03-30
被引量:1
摘要
The American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) 1987 classification for rheumatoid arthritis (RA) focuses on four main clinical findings without emphasizing biomarker serology. On the other hand, the updated ACR/EULAR 2010 classification relies more on acute-phase reactants and biomarker serology. While a positive rheumatoid factor (RF) and positive anti-citrullinated protein antibody (ACPA) are specific for RA, at least 15%-25% of patients are seronegative. Given that the ACR/EULAR 2010 classification is more likely to miss these seronegative patients, clinical judgment is important while assessing patients to avoid delays in diagnosis and onset of treatment.
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