骨愈合
伤口愈合
自愈
材料科学
化学
复合材料
生物医学工程
医学
外科
病理
替代医学
作者
Yanran Zhao,Tengjiao Zhu,Shuai Han,Yanlei Dong,Yi Zhou,Yan Qiao,Yun Tian,Dong Qiu,Xiaozhong Qu
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2023-04-05
卷期号:24 (5): 2075-2086
被引量:2
标识
DOI:10.1021/acs.biomac.2c01503
摘要
Development of bioactive bone and joint implants that offer superior mechanical properties to facilitate personalized surgical procedures remains challenging in the field of biomedical materials. As for the hydrogel, mechanical property and processability are major obstructions hampering its application as load-bearing scaffolds in orthopedics. Herein, we constructed implantable composite hydrogels with appealing processability and ultrahigh stiffness. Central to our design is the incorporation of a thixotropic composite network into an elastic polymer network via dynamic interactions to synthesize a percolation-structured double-network (DN) hydrogel with plasticity, followed by in situ strengthening and self-strengthening mechanisms for fostering the DN structure to the cojoined-network structure and subsequently mineralized-composite-network structure to harvest excellent stiffness. The ultrastiff hydrogel is shapeable and can reach a compressive modulus of 80–200 MPa together with a fracture energy of 6–10 MJ/m3, comparable to the mechanical performance of cancellous bone. Moreover, the hydrogel is cytocompatible, osteogenic, and showed almost no volume shrinkage within 28 days in simulated body fluid or culture medium. Such characteristics enabled the utility of a hydrogel in the reduction and stabilization of periarticular fracture treatment on a distal femoral AO/OTA B1 fracture rabbit model and successfully avoided the recollapse of the articular surface.
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