生物年龄
生命银行
疾病
器官系统
医学
慢性病
老年学
生物信息学
生物
重症监护医学
病理
作者
Ye Tian,Vanessa Cropley,Andrea B. Maier,Nicola T. Lautenschlager,Michael Breakspear,Andrew Zalesky
出处
期刊:Nature Medicine
[Springer Nature]
日期:2023-04-06
卷期号:29 (5): 1221-1231
被引量:175
标识
DOI:10.1038/s41591-023-02296-6
摘要
Biological aging of human organ systems reflects the interplay of age, chronic disease, lifestyle and genetic risk. Using longitudinal brain imaging and physiological phenotypes from the UK Biobank, we establish normative models of biological age for three brain and seven body systems. Here we find that an organ's biological age selectively influences the aging of other organ systems, revealing a multiorgan aging network. We report organ age profiles for 16 chronic diseases, where advanced biological aging extends from the organ of primary disease to multiple systems. Advanced body age associates with several lifestyle and environmental factors, leukocyte telomere lengths and mortality risk, and predicts survival time (area under the curve of 0.77) and premature death (area under the curve of 0.86). Our work reveals the multisystem nature of human aging in health and chronic disease. It may enable early identification of individuals at increased risk of aging-related morbidity and inform new strategies to potentially limit organ-specific aging in such individuals.
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