光动力疗法
光敏剂
纳米颗粒
生物物理学
化疗
癌症研究
材料科学
三磷酸腺苷
化学
纳米技术
光化学
医学
生物化学
外科
生物
有机化学
作者
Zehou Su,Dongmei Xi,Yingchao Chen,Ran Wang,Xiaolong Zeng,Tao Xiong,Xiang Xia,Rong Xiang,Ting Liu,Wenkai Liu,Jianjun Du,Jiangli Fan,Xiaojun Peng,Wen Sun
出处
期刊:Small
[Wiley]
日期:2023-01-01
卷期号:19 (11)
被引量:21
标识
DOI:10.1002/smll.202205825
摘要
The combination of photodynamic therapy (PDT) and chemotherapy (chemo-photodynamic therapy) for enhancing cancer therapeutic efficiency has attracted tremendous attention in the recent years. However, limitations, such as low local concentration, non-suitable treatment light source, and uncontrollable release of therapeutic agents, result in reduced combined treatment efficacy. This study considered adenosine triphosphate (ATP), which is highly upregulated in tumor cells, as a biomarker and developed ingenious ATP-activated nanoparticles (CDNPs) that are directly self-assembled from near-infrared photosensitizer (Cy-I) and amphiphilic Cd(II) complex (DPA-Cd). After selective entry into tumor cells, the positively charged CDNPs would escape from lysosomes and be disintegrated by the high ATP concentration in the cytoplasm. The released Cy-I is capable of producing single oxygen (1 O2 ) for PDT with 808 nm irradiation and DPA-Cd can concurrently function for chemotherapy. Irradiation with 808 nm light can lead to tumor ablation in tumor-bearing mice after intravenous injection of CDNPs. This carrier-free nanoparticle offers a new platform for chemo-photodynamic therapy.
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