炎症体
目标2
NLRC4型
分泌物
脂多糖
炎症
活性氧
化学
半胱氨酸蛋白酶1
细胞生物学
生物化学
生物
免疫学
作者
Gilyoung Lee,Huijeong Ahn,Jang-Hyuk Yun,Jeong-Ho Park,Eunsong Lee,Seikwan Oh,Geun‐Shik Lee
标识
DOI:10.1038/s41598-022-27129-3
摘要
Dysregulation of inflammasome activation induces chronic and excess inflammation resulting in several disorders, such as metabolic disorders and cancers. Thus, screening for its regulator derived from natural materials has been conducted progressively. JC2-11 (JC) was designed to enhance the antioxidant activity based on a chalcone, which is abundant in edible plants and a precursor of flavonoids. This study examined the effects of JC on inflammasome activation in human and murine macrophages. JC inhibited the secretion of interleukin (IL)-1β and lactate dehydrogenases, and the cleavage of caspase-1 and gasdermin D in response to the tested activators (i.e., NLRP3, NLRC4, AIM2, and non-canonical inflammasome triggers). In addition, JC attenuated IL-1β secretion from lipopolysaccharide (LPS)-injected mice, an inflammasome-mediating disease model. Mechanistically, JC blocked the expression of the inflammasome components during the priming step of the inflammasome, and interrupted the production of mitochondrial reactive oxygen species. In addition, JC inhibited the activity of caspase-1. In conclusion, JC may be a candidate pan-inflammasome inhibitor.
科研通智能强力驱动
Strongly Powered by AbleSci AI